5.2 Drug Delivery System
5.2.1 Advantage of Nano-drug delivery system
By diagnosis, and for treatment, we need enhanced drug delivery system. Drug delivery system of these days is just eat and let it flow through the body. It is not good at efficiency. Because the digestive system sometimes digest and remove the drug before it reaches to the target.
For enhancing the efficiency of drug
task currently important.
Regulation of nanoparticles.
Size : 10~100nm (EPR effect)
Coating PEG polymer
Why nanoparticles?
1) It can deliver a larger quantity of drugs with better safety.
2) Easy to attach targeting ligands.
3) It is enough size to deliver multi-drugs.
4) Can regulate releasing of drug particles.
5) Can avoid multidrug resistance through cell-surface protein pump.
모든 형태의 방출조설 system의 궁극적인 목표는 약품을 투여하고자하는 목표 조직에 약품을 특정한 시간동안 조절된 속도로서 전달하고자하는 것이다. 이와 같은 목적을 달성하기 위해서는 여러 가지 parameter에 대한 깊은 이해가 필요하며 방출조절 system을 개발하는데 있어서 고려되어야할 몇 가지 사
*’Nano’ means….
Nanometer: one billionth of a meter
Nano-: prefix comes from the Greek word for ‘dwarf’
Chemical, physical, and biological properties that differ from those of their larger, or bulk counterparts
Nanotechnology: The National Nanotechnology Initiative(NNI)-> the science of materials and phenomena in the range of 1 to 100nm in diameter
*Features of ‘nanoparticles
1. Introduction
1) Definition of preservation and food-spoilage micro-organisms
Food preservation is the process of treating and handling food to stop or greatly slow down spoilage (loss of quality, edibility or nutritive value) caused or accelerated by micro-organisms. Some methods, however, use benign bacteria, yeasts or fungi to add specific qualities and to preserve food (e.g., cheese, wine
반응을 검출. (b)는 항원을 표면에 고정하고 면역반응을 하고 반응 정도를 표식 물질로 측정.
Figure 4 단백질 칩에서 고체 표면에 결합된 단백질의 모식도를 표현. 세번째는 표식된 물질에서 나타나는 색의 변화를 보고 생체반응을 정량화 한다.
<ProteinChip 시스템의 예>
• Ciphergen Biosystems
system
(Gear 방식으로 Cam 방식보다 Pulse가 적다.)
c. 가동이 쉽고 여러 용매 사용 가능.
d. Isocratic에서 Gradient까지 사용.
e. 내구성이 우수.
.
.
.
HPLC grade solvent가 물인경우 18 mega ohm이상.
Low Viscosity
용매간 섞임성. (miscibility No. 차가 15미만 )
이동상은 고정상을 변화시키면 안된다.
분리코자 하는 시료